Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis.

Nitsan Sharon, Yvonne Ventura, Nirit Bernstein, Jonathan Gorelick, Shimon Ben-Shabat, Sigal Fleisher-Berkovich

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nitsan SharonDepartment of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva P.O. Box 653, Israel.ORCID 0009-0004-2899-1472

Yvonne VenturaDepartment of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva P.O. Box 653, Israel.

Nirit BernsteinInstitute of Soil Water and Environmental Sciences, Volcani Center, Rishon LeZion 15159, Israel.

Jonathan GorelickEastern Regional Research and Development Center, Judea Center, Kiryat Arba 90100, Israel.

Shimon Ben-ShabatDepartment of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva P.O. Box 653, Israel.ORCID 0000-0001-7551-5488

Sigal Fleisher-BerkovichDepartment of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva P.O. Box 653, Israel.ORCID 0000-0002-0797-8816

Funding

Israel Science Foundation 634/24

6 · The paper itself

Abstract

Neuroinflammation is a hallmark of multiple sclerosis (MS). MS is marked by glial cell activation, autoreactive T cells, and the release of pro-inflammatory cytokines and free radicals. Current therapeutic strategies aim to modulate the immune response using disease-modifying therapies, to slow disease progression. The specific aims of this study were: (a) to investigate the effect of cannabinoid acids on the release of glial neuroinflammatory mediators, (b) to examine the effect of intraperitoneally administered cannabinoid acids on symptoms of MS, and (c) to evaluate their effects on microglial and astrocyte activation and CD4

Indexed as

CannabinoidsEncephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisNeurogliaAnimalsBiomarkersBlood-Brain BarrierCD4-Positive T-LymphocytesCell LineDronabinolFemaleMiceMice, Inbred C57BLNeuroinflammatory DiseasesPrimary Cell CultureRatsBiomarkerscannabidiolic acidCannabinoidsdelta(1)-tetrahydrocannabinolic acidDronabinolcannabinoid acidslipopolysaccharidemicrogliamultiple sclerosisneuroinflammation

Identifiers

PMID41976267

DOI10.3390/molecules31071227

PMCPMC13074990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.