ArticleMolecules (Basel, Switzerland)2026
Dual-Action Sutures: Chlorhexidine and Dexamethasone for Infection Control and Inflammation Suppression.
Brisa Guadalupe Hernández-Ramírez, Giovanni Palomino-Vizcaino, Lilia Angélica Hurtado-Ayala, Jonathan Vincent Lopez-Baena, Hebrón Vazquez-Estudillo, Arturo Estolano-Cobián, Teresa G Rodriguez-Tellez, Héctor Milla-Hinojosa, José Manuel Cornejo-Bravo, Kenia Palomino-Vizcaino and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Brisa Guadalupe Hernández-RamírezFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0009-0000-4933-144X Giovanni Palomino-VizcainoFaculty of Health Sciences, Autonomous University of Baja California, University Boulevard 1000, Valle de Las Palmas, Tijuana 22260, Mexico.ORCID 0000-0001-8905-7377 Lilia Angélica Hurtado-AyalaFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0000-0003-4966-031X Jonathan Vincent Lopez-BaenaFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0000-0001-7978-4378 Hebrón Vazquez-EstudilloFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0009-0007-0407-2377 Arturo Estolano-CobiánFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.
Teresa G Rodriguez-TellezFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.
Héctor Milla-HinojosaTjplast Outpatient, 9288 Heroes Avenue, Rio Zone, Tijuana 22010, Mexico.
José Manuel Cornejo-BravoFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0000-0002-0013-8937 Kenia Palomino-VizcainoFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0000-0001-5650-2913 Héctor MagañaFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard 14418, International Industrial Park Tijuana, Tijuana 22390, Mexico.ORCID 0000-0001-7977-8023 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Surgical site infections (SSIs) remain a major clinical challenge, particularly due to bacterial adhesion and biofilm formation on suture materials. In this study, we developed a dual drug-eluting suture incorporating chlorhexidine (CHX) and dexamethasone (DEX), with lauric acid used as a binding agent to enhance drug adhesion. The exact composition of the system was CHX/DEX/Lauric Acid, designed to enable localized delivery of both therapeutic agents at the implantation site. Vicryl sutures were dip-coated and characterized by means of FTIR-ATR and HPLC to confirm drug incorporation and release. Mechanical integrity was preserved, with no significant difference in tensile strength between coated and uncoated sutures. Antimicrobial activity was confirmed against Gram-positive and -negative bacteria, including methicillin-resistant
Indexed as
ChlorhexidineDexamethasoneInflammationSurgical Wound InfectionSuturesAnti-Inflammatory AgentsBacterial AdhesionCandida albicansHumansLauric AcidsMethicillin-Resistant Staphylococcus aureusAnti-Inflammatory AgentsChlorhexidineDexamethasonelauric acidLauric Acidschlorhexidinedexamethasonedrug-eluting suturedrug release systemdual drug-eluting suturefunctionalized sutureinhibition zone testsurgical site infectionsurgical suture
Identifiers
PMID41976240
PMCPMC13074332
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