Nickel-Catalyzed Intermolecular Cyclization of 2-Bromobenzamide: A General Strategy for Synthesizing 6(5H)-Phenanthridinone Derivatives.

Xinsheng Xiao, Xueli Zhu, Yan Shu, Bowen Zhang, Changhui Zhao, Asad Nawaz, Zunhua Li

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xinsheng XiaoCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Xueli ZhuCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Yan ShuCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Bowen ZhangSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Changhui ZhaoCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Asad NawazCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Zunhua LiCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Funding

the Construct Program of Applied Characteristic Discipline in Hunan Province. Nonethe Guiding Science and Technology Planning Project of Yongzhou City 2024YZ015the Natural Science Foundation of Hunan Province 2023JJ50068the Natural Science Foundation of Hunan Province 2026JJ80559the Scientific Research Project of Hunan University of Science and Engineering 23XKYZZ01

6 · The paper itself

Abstract

6(5H)-phenanthridinone derivatives, as an important class of alkaloids, have broad application value in drug development and functional material synthesis. In this study, a nickel-catalyzed synthetic strategy was developed, using 2-bromobenzamide compounds as starting materials. Through an intermolecular cyclization reaction, a series of 6(5H)-phenanthridinone derivatives bearing amide substituents was efficiently constructed. The optimal reaction system was identified: Ni(acac)

Indexed as

2-bromobenzanilideintermolecular cyclizationnickel catalysisphenanthridinone

Identifiers

PMID41976218

DOI10.3390/molecules31071176

PMCPMC13074239

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