Evidence map›Paper›PMID 41976183›Full record

ArticleMolecules (Basel, Switzerland)2026

Selective Cytotoxicity of Sodium Enone Salts Through Mitochondrial Dysfunction and Cell Cycle Arrest in Human Cancer Cells.

Nikola Mirković, Marina Mitrović, Mirela Jevtić, Katarina Pantić, Petar Čanović, Ivana Nikolić, Stefan Jakovljević, Marina Kostić, Jelena Živić, Jelena Nešić and 5 more

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nikola MirkovićDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Marina MitrovićDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Mirela JevtićDepartment of Gynecology and Obstetrics, General Hospital Užice, 31000 Užice, Serbia.
Katarina PantićFaculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0002-5806-7174
Petar ČanovićDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Ivana NikolićDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Stefan JakovljevićDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Marina KostićDepartment of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Jelena ŽivićDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Jelena NešićDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Nenad ZornićDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Stevan ErićDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Jovana MuškinjaDepartment of Science, Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, Serbia.
Marija ŠorakDepartment of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0002-3571-0091
Marija AnđelkovićDepartment of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.

Funding

Faculty of Medical Sciences University of Kragujevac Grant No: JP 16/22Serbian Ministry of Science, Technological Development, and Innovations Agreement No. 451-03-136/2025-03/200111Serbian Ministry of Science, Technological Development, and Innovations Agreement No. 451-03-137/2025-03/200111
6 · The paper itself

Abstract

Recent advances in enone chemistry have enabled the development of structurally optimized derivatives with improved anticancer selectivity. In this study, the cytotoxic activity and underlying mechanisms of sodium salts of four α,β-unsaturated enones (ES1-ES4), synthesized from vanillin-based scaffolds, were evaluated in human colorectal carcinoma (HCT-116), cervical adenocarcinoma (HeLa), and normal lung fibroblast (MRC-5) cell lines. All compounds exhibited concentration- and time-dependent cytotoxicity, with ES2 showing the highest potency (IC

Indexed as

Antineoplastic AgentsCell Cycle CheckpointsKetonesMitochondriaApoptosisBenzaldehydesCell Line, TumorCell ProliferationHCT116 CellsHeLa CellsHumansMembrane Potential, MitochondrialSaltsAntineoplastic AgentsBenzaldehydesKetonesSaltsenone saltsHCT-116HeLamitochondrial apoptosisvanillin derivatives

Identifiers

PMID41976183
PMCPMC13075022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.