Evidence map›Paper›PMID 41976180›Full record

ArticleMolecules (Basel, Switzerland)2026

An In Silico and In Vitro Approach Identified Potential Trypanothione Synthetase Inhibitors with Trypanocidal Activity.

Rogelio Gómez-Escobedo, Domingo Méndez-Álvarez, Alma D Paz-González, Eyra Ortiz-Pérez, Lenci K Vázquez-Jiménez, Ana Verónica Martínez-Vázquez, Timoteo Delgado-Maldonado, José M Quintero-Solano, Citlali Vázquez, Emma Saavedra and 4 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rogelio Gómez-EscobedoDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Domingo Méndez-ÁlvarezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Alma D Paz-GonzálezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Eyra Ortiz-PérezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0003-3800-0228
Lenci K Vázquez-JiménezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0002-9327-9658
Ana Verónica Martínez-VázquezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0002-6144-5439
Timoteo Delgado-MaldonadoLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-8915-7351
José M Quintero-SolanoLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0009-0006-5729-3344
Citlali VázquezDepartamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
Emma SaavedraDepartamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.ORCID 0000-0001-8661-9813
Guadalupe Avalos-NavarroDepartamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega (CUCIÉNEGA), Universidad de Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, Mexico.ORCID 0000-0003-1121-607X
Karina VázquezFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, C. Francisco Villa 20, Hacienda del Cañada, General Escobedo 66054, Mexico.
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-9842-4167
Benjamín Nogueda-TorresDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.ORCID 0000-0001-9564-7066

Funding

Secretaria de Investigacion y Posgrado del Instituto Politecnico Nacional 20250835
6 · The paper itself

Abstract

In this study, a drug repurposing strategy was implemented with the aim of identifying new trypanocidal agents against

Indexed as

Amide SynthasesEnzyme InhibitorsTrypanocidal AgentsTrypanosoma cruziAnimalsCatalytic DomainChagas DiseaseComputer SimulationDrug RepositioningMiceMolecular Docking SimulationMolecular Dynamics SimulationAmide SynthasesEnzyme InhibitorsTrypanocidal Agentstrypanothione synthetaseChagas diseaseFDA drugsmolecular dockingrepositioningtrypanothione synthetase

Identifiers

PMID41976180
PMCPMC13074970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.