ArticleMolecules (Basel, Switzerland)2026
An In Silico and In Vitro Approach Identified Potential Trypanothione Synthetase Inhibitors with Trypanocidal Activity.
Rogelio Gómez-Escobedo, Domingo Méndez-Álvarez, Alma D Paz-González, Eyra Ortiz-Pérez, Lenci K Vázquez-Jiménez, Ana Verónica Martínez-Vázquez, Timoteo Delgado-Maldonado, José M Quintero-Solano, Citlali Vázquez, Emma Saavedra and 4 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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1 · What the graph read from itWhat it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Rogelio Gómez-EscobedoDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Domingo Méndez-ÁlvarezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Alma D Paz-GonzálezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Eyra Ortiz-PérezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0003-3800-0228 Lenci K Vázquez-JiménezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0002-9327-9658 Ana Verónica Martínez-VázquezLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0002-6144-5439 Timoteo Delgado-MaldonadoLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-8915-7351 José M Quintero-SolanoLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0009-0006-5729-3344 Citlali VázquezDepartamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
Emma SaavedraDepartamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.ORCID 0000-0001-8661-9813 Guadalupe Avalos-NavarroDepartamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega (CUCIÉNEGA), Universidad de Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, Mexico.ORCID 0000-0003-1121-607X Karina VázquezFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, C. Francisco Villa 20, Hacienda del Cañada, General Escobedo 66054, Mexico.
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-9842-4167 Benjamín Nogueda-TorresDepartamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.ORCID 0000-0001-9564-7066 Funding
Secretaria de Investigacion y Posgrado del Instituto Politecnico Nacional 20250835
6 · The paper itselfAbstract
In this study, a drug repurposing strategy was implemented with the aim of identifying new trypanocidal agents against
Indexed as
Amide SynthasesEnzyme InhibitorsTrypanocidal AgentsTrypanosoma cruziAnimalsCatalytic DomainChagas DiseaseComputer SimulationDrug RepositioningMiceMolecular Docking SimulationMolecular Dynamics SimulationAmide SynthasesEnzyme InhibitorsTrypanocidal Agentstrypanothione synthetaseChagas diseaseFDA drugsmolecular dockingrepositioningtrypanothione synthetase
Identifiers
PMID41976180
PMCPMC13074970
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