Evidence map›Paper›PMID 41976038›Full record

ArticleAnimals : an open access journal from MDPI2026

Pathogenicity of a Canine-Derived Feline Panleukopenia Virus in Cats and NS1 Evolution Associated with Adaptation to Dogs.

Jiayi Wu, Qiqi Chen, Yin Zhang, Xinyuan Hu, Yongtao Li, Menghua Tang, Qingting Yu, Hua Yue, Cheng Tang, Xi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiayi WuKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Qiqi ChenKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Yin ZhangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Xinyuan HuKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Yongtao LiCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.
Menghua TangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Qingting YuAnimal Husbandry Science Institute of Ganzi Tibetan Autonomous Prefecture, Kangding 626000, China.
Hua YueKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0002-8413-7260
Cheng TangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.
Xi ChenKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu 610041, China.

Funding

Innovation Fund of the International Joint Research Center of National Animal Immunology 2025IJRCNAI12Sichuan Science and Technology Program 2024NSFSC1283the Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System SCCXTD-2024-18the Southwest Minzu University Research Startup Funds RQD2023035
6 · The paper itself

Abstract

Feline panleukopenia virus (FPV) is a major feline pathogen, but canine-derived FPV variants have recently been identified. Here, we compared the pathogenicity of a canine-derived FPV strain in cats with that of a lethal feline-derived FPV strain and evaluated the evolutionary significance of its NS1 mutations. Kittens infected with the canine-derived strain developed only mild, self-limiting diarrhea without fever or mortality, whereas those infected with the feline-derived strain developed severe disease and reached humane endpoints by 9 dpi. The canine-derived strain caused prolonged fecal shedding from 6 to 38 dpi but only low tissue viral loads (10

Indexed as

attenuated virulencecanine-derived variantcross-species transmissionfeline panleukopenia virushost adaptationkittensNS1 mutationsviral shedding

Identifiers

PMID41976038
PMCPMC13071982

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.