Evidence map›Paper›PMID 41975746›Full record

ArticleDiagnostics (Basel, Switzerland)2026

The Nose-Lung Axis in Chronic Obstructive Pulmonary Disease: An Emerging Interface for Clinical Endotyping, Biomarker Discovery, and Integrated Management.

Pasquale Ambrosino, Giuseppina Marcuccio, Claudio Candia, Fabio Manzo, Christian Basile, Guido Grassi, Mauro Maniscalco

Abstract readEditorial
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, Scientific Directorate of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0002-9398-0428
Giuseppina MarcuccioIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy.
Claudio CandiaIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0002-5888-8781
Fabio ManzoFleming Clinical Laboratory, 81020 Casapulla, Italy.ORCID 0009-0005-7493-5954
Christian BasileDepartment of Clinical Science and Education, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-4680-3058
Guido GrassiDepartment of Medicine and Surgery, Milano-Bicocca University, 20126 Milan, Italy.
Mauro ManiscalcoIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0001-6751-9921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) continues to be framed predominantly as a disorder of the lower airways, defined operationally by airflow limitation, and assessed through a combination of spirometry, symptom burden, and exacerbation history [...].

Identifiers

PMID41975746
PMCPMC13073355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.