ReviewDiagnostics (Basel, Switzerland)2026
Potential Benefits of Ultra-High Field MRI for Embryonic and Fetal Brain Investigation: A Comprehensive Review.
Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
10 authors.
Funding
Abstract
Ultra-high-field (UHF) magnetic resonance imaging, defined as imaging at field strengths of 7 Tesla (7T) and above, represents a frontier technology in neuroimaging with emerging applications in prenatal brain research. This narrative review examines the current evidence on the potential benefits of UHF-MRI for investigating embryonic and fetal brain development. Through analysis of 97 studies identified across multiple databases, we find that UHF-MRI offers substantial advantages in spatial resolution, tissue contrast, and anatomical detail compared to conventional clinical field strengths (1.5T and 3T). The primary applications to date have been in ex vivo imaging of post-mortem fetal specimens and preclinical animal models, where UHF-MRI has enabled unprecedented visualization of laminar cortical organization, early sulcation patterns, microstructural development, and subtle anatomical features critical for understanding normal and abnormal neurodevelopment. Key benefits include enhanced delineation of transient developmental zones, improved characterization of cortical folding, superior detection of subtle malformations, and the ability to create high-resolution three-dimensional atlases of fetal brain development. However, significant technical and safety challenges currently limit in utero human applications, including concerns about specific absorption rate, acoustic noise, and fetal motion artifacts. This review identifies critical knowledge gaps and future directions for translating UHF-MRI technology to clinical prenatal diagnostics.
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Registered trials
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