ArticleBiomedical engineering online2026
Synergistic enhancement of peripheral nerve regeneration using electrospun polylactic acid conduits with leupeptin and methylprednisolone in rats.
Article in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Peripheral nerve injuries pose significant clinical challenges, leading to sensory and motor impairments, neuralgia, and socioeconomic burdens due to suboptimal recovery. This study evaluated the efficacy of electrospun polylactic acid (PLA) conduits combined with leupeptin and methylprednisolone for nerve regeneration in a rat sciatic nerve defect model. Fifty adult male Sprague-Dawley rats were randomized into five groups (n = 10/group): control, saline, leupeptin (0.5 mg/mL), glucocorticoid (30 mg/mL methylprednisolone), and combined (leupeptin + methylprednisolone). A 10-mm sciatic nerve gap was created and bridged with PLA conduits filled with the respective treatments. Functional recovery was assessed via the sciatic functional index (SFI) from weeks 4-16 postsurgery. Histological analyses (hematoxylin-eosin, Masson, and Ponceau red staining) and immunofluorescence for collagen I/III were performed at week 16. The combined group showed significantly higher SFI scores (e.g., - 20.5 ± 4.2 at week 16 vs. - 45.3 ± 5.1 in saline; P < 0.001), enhanced regeneration, reduced fibrosis, and improved myelination compared to others. These results indicate that the combined approach optimizes the regenerative microenvironment, warranting further translational studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.