Trial reportBMC oral health2026
Postoperative pain after single visit root canal treatment using domestic vs. medical grade sodium hypochlorite: a randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07248189 (Postoperative Pain After Single Visit Root Canal Treatment Using Commercial or Medical Grade Sodium Hypochlorite as Irrigating Solutions in Patients With Symptomatic Irreversible Pulpitis in Their Mandibular Molars), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Postoperative Pain After Single Visit Root Canal Treatment Using Commercial or Medical Grade Sodium Hypochlorite as Irrigating Solutions in Patients With Symptomatic Irreversible Pulpitis in Their Mandibular Molars: A Randomized Controlled Trial
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSodium hypochlorite (NaOCl), the primary endodontic disinfectant, is available in both domestic-grade products and specialized medical-grade formulations. The stability and concentration of domestic-grade products are inconsistent, potentially affecting safety and clinical outcomes. This trial compared the impact of domestic-grade versus medical-grade NaOCl on postoperative pain following endodontic treatment in patients with symptomatic irreversible pulpitis. METHODOLOGY: Sixty participants with symptomatic irreversible pulpitis in mandibular molars were randomly distributed into two groups (n = 30). Following instrumentation with Edge X7 rotary files, Group A received domestic-grade NaOCl irrigation, while Group B was treated with a medical-grade formulation. Participants recorded pain intensity on an 11-point numerical rating scale (NRS) at 6, 12, 24, 48, and 72 h.
resultsDomestic-grade NaOCl was associated with significantly higher pain levels at 6 h (median 3 vs. 0; p < 0.05) and 12 h (median 2 vs. 0; p < 0.05) compared to medical-grade NaOCl. No significant differences were observed at 24, 48, or 72 h.
conclusionsDomestic bleach caused significantly higher early postoperative pain than medical-grade sodium hypochlorite due to its unstandardized, higher concentration. Standardized medical-grade irrigants are recommended to maximize patient comfort and clinical predictability.
trial registrationThe protocol for this prospective, parallel group, double blinded, randomized clinical trial was registered at ClinicalTrials.gov ( https://register.clinicaltrials.gov/ ) on 18/11/2025, registration number (NCT07248189). The trial was retrospectively registered.
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