Trial reportBMC geriatrics2026
Preserving brain health in aging: structural and biochemical benefits of water based resistance training, a randomized controlled trial.
Trial report in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
backgroundBrain aging leads to structural changes, especially atrophy, which can result in dysfunction. Mitochondrial dysfunction is thought to explain the structural changes in brain aging.
objectiveThis study aimed to investigate the effects of a 12-week water-based resistance training (WBRT) program on brain structural integrity, mitochondrial-related growth factors, oxidative stress, and inflammation in older women.
methodsA total of 24 older women (mean age:66) were randomly assigned to a WBRT group (n = 12) or a control (CON) group (n = 12). Participants in the WBRT group performed supervised resistance training in water three times per week for 12 weeks. Brain structural changes were assessed using magnetic resonance imaging (MRI), and blood samples were analyzed for Humanin (HN), Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF-15), Brain-Derived Neurotrophic Factor (BDNF), and Insulin-like Growth Factor 1 (IGF-1) as well as oxidative and inflammation biomarkers.
resultsThe WBRT group showed significant increases in gray matter, subcortical gray matter, cerebellar gray matter volume, and cerebrum white matter compared to the CON group (p < 0.05). Furthermore, WBRT resulted in significant increases in BDNF, IGF-1, FGF21, and GDF-15 levels (p < 0.05). Malondialdehyde decreased, and glutathione peroxidase increased, with significant reductions in tumor necrosis factor-alpha and an increase in interleukin-10 in the WBRT group compared to the CON group (p < 0.05), suggesting anti-inflammatory and antioxidant effects of WBRT.
conclusionThese findings support the potential beneficial effects of WBRT as an non-pharmacological intervention to counteract age-related brain atrophy and promote brain health in aging populations.
trial registrationIR.KMU.REC.1402.068, 29/06/2023
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