Evidence map›Paper›PMID 41975274›Full record

ArticleGut microbes2026

Compositional and functional differences of gut microbiome and metabolome inform pathogenesis of cholestatic liver disease.

Marios Nikolaidis, Chang Hu, Brian D Juran, Bryan M McCauley, Erik M Schlicht, Jackie K Bianchi, Ahmad H Ali, Venetia Tragaki, Elizabeth J Atkinson, Stephen Johnson and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Marios NikolaidisDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3902-9367
Chang HuDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Brian D JuranDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Bryan M McCauleyDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Erik M SchlichtDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Jackie K BianchiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Ahmad H AliDivision of Gastroenterology and Hepatology, School of Medicine, University of Missouri, Columbia, MO, USA.
Venetia TragakiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Elizabeth J AtkinsonDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Stephen JohnsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Ruben A MarsDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
John E EatonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Elizabeth J CareyLiver Transplant Program, Transplant Center, Mayo Clinic Arizona, Phoenix, AZ, USA.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID 0000-0003-1530-5811
Christoph SchrammDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Purna C KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2851-2388
Young-Mi GoClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
ViLinh TranClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
Sami TeenyClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
Dean P JonesClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
Caroline W GrantDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Arjun P AthreyaDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Center for Innovative Exposomics, Columbia University, New York, NY, USA.
Nicholas F LaRussoDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Gregory J GoresDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Tom H KarlsenNorwegian PSC Research Center, Department of Transplant Medicine and Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway.
Johannes R HovNorwegian PSC Research Center, Department of Transplant Medicine and Research Institute of Internal Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-5900-8096
Grigorios D AmoutziasBioinformatics Laboratory, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Konstantinos N LazaridisDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0437-681X

Funding

Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genomeRC2DK118619 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2018 to 2022
$7.8M
Pathogenesis of Primary Biliary CholangitisR01DK126691 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2021 to 2024
$2.6M
NIDDK NIH HHS R01 DK126691NIDDK NIH HHS RC2 DK118619
6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are rare, idiopathic, chronic cholestatic liver diseases that respond differently to limited medical therapies and often lead to liver transplantation. We examined the compositional and functional differences in the gut microbiome, mycobiome, and metabolome of these diseases to better understand their impact on pathogenesis and outcomes. Stool sample metagenomes and metabolomes from patients with PSC (

Indexed as

BacteriaCholangitis, SclerosingGastrointestinal MicrobiomeLiver Cirrhosis, BiliaryMetabolomeAdultAgedFecesFemaleHumansMaleMetabolomicsMetagenomeMiddle AgedBacteriacholestatic diseasefungigut microbiotametabolomicsmetagenomicsmicrobiomephage therapiesprobioticsSCFA

Identifiers

PMID41975274
PMCPMC13078198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.