ArticleMicrobiologyOpen2026
Genomic Insights Into a Hospital-Acquired High-Risk Vancomycin-Resistant Enterococcus faecium Outbreak in Guangdong, China.
Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Can Artificial Intelligence Transform Early Warning for Antimicrobial-Resistant Outbreak Clones? Approaches, Gaps, and Opportunities: A Scoping Review.Antibiotics (Basel, Switzerland) · 2026Review
- Genomic Insights Into a Hospital-Acquired High-Risk Vancomycin-Resistant Enterococcus faecium Outbreak in Guangdong, China.MicrobiologyOpen · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A comprehensive molecular epidemiological study was conducted on a vancomycin-resistant Enterococcus faecium (VR-Efm) outbreak in Guangdong, China, with the aim of analyzing transmission routes and antimicrobial resistance patterns, developing specific diagnostic tools for early detection, and elucidating genetic relationships with previously reported strains. Strain identification was performed using matrix-assisted laser desorption/ionization mass spectrometry, whereas whole-genome sequencing was performed for bacterial genomic characterization. Comprehensive bioinformatic analyses, including multilocus sequence typing, phylogenetic tree construction, principal component analysis, minimum spanning tree, and comparative genomic analyses, were performed. Our genomic investigation identified as predominant the sequence type 80 strain of VR-Efm, which exhibited a high level of resistance to a range of antibiotics, particularly vancomycin, amoxicillin, and teicoplanin. Through genome sequencing, we established genetic proximity between the outbreak strain and those previously identified in India and Japan. Furthermore, functional genomic analyses have elucidated genetic variations within critical genes, such as rsmH, which may be associated with the acquisition of antibiotic resistance. The identification of unique molecular markers within the outbreak strain facilitated the development of specific PCR assays, thereby significantly enhancing our capacity for early and precise detection of VR-Efm. Our in-depth genomic analysis of the VR-Efm outbreak in Guangdong, China, identified a predominant ST80 strain that exhibited multidrug resistance, especially to vancomycin. This finding underscores the need for enhanced global public health surveillance to address this emerging threat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.