Evidence map›Paper›PMID 41975232›Full record

Trial reportNursing in critical care2026

From Intensive Care to Recovery: Feasibility of a Randomised Controlled Study Design Evaluating a Cognitive Rehabilitation Intervention for Critically Ill Patients.

Katrine Astrup, Helene Korvenius Nedergaard, Pia Dreyer, Anna Holm, Mette Møller, Trine Nørskov Haberlandt, Rikke Sig, Nanna Rolving

Abstract readRandomized Controlled TrialPragmatic Clinical Trial
In one paragraph

Trial report in Nursing in critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrine AstrupDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5007-3927
Helene Korvenius NedergaardDepartment of Anaesthesiology and Intensive Care, University Hospital of Southern Denmark, Lillebaelt Hospital Kolding, Kolding, Denmark.ORCID https://orcid.org/0000-0002-5988-4563
Pia DreyerDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3581-7438
Anna HolmDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-2582-4984
Mette MøllerDepartment of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0009-0004-0005-8146
Trine Nørskov HaberlandtDepartment of Anaesthesiology and Intensive Care, University Hospital of Southern Denmark, Lillebaelt Hospital Kolding, Kolding, Denmark.
Rikke SigDepartment of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0009-0005-6017-0305
Nanna RolvingDepartment of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-9195-7278

Funding

Aarhus UniversitetNovo Nordisk Fonden NNF20OC0061394
6 · The paper itself

Abstract

backgroundSurvivors of critical illness frequently experience persistent cognitive impairment. However, structured cognitive rehabilitation interventions remain limited within intensive care pathways. While physical rehabilitation has received increasing attention, evidence guiding cognitive rehabilitation in intensive care unit (ICU) populations is sparse, and the feasibility of study procedures must be established before large-scale evaluation.

aimTo assess the feasibility of conducting a multi-arm randomised controlled trial evaluating a cognitive rehabilitation intervention (ICU CogHab) for ICU survivors. STUDY

designA pragmatic, five-arm randomised feasibility study was conducted across four ICUs at two Danish university hospitals. Feasibility outcomes included screening and recruitment, randomisation procedures, retention through 6-month follow-up and completion of patient-reported and performance-based outcome measures. Data were analysed descriptively to summarise feasibility parameters and outcome variability.

resultsOf 1679 patients screened, 115 met eligibility criteria and 83 were randomised. Recruitment was lower than anticipated, and retention at 6 months was 40%. Clinical data obtained from medical records were largely complete, whereas cognitive and patient-reported outcomes were more difficult to complete at ICU discharge. Outcome measures demonstrated substantial variability.

conclusionThis study shows that screening and randomisation procedures for a cognitive rehabilitation intervention are feasible within routine ICU practice. Retention and data completeness, particularly after hospital discharge, represent key challenges requiring refinement before further evaluation. RELEVANCE TO CLINICAL PRACTICE: Cognitive rehabilitation can be introduced within routine ICU workflows. However, the timing of assessments, follow-up procedures and integration into clinical practice require optimisation. These findings inform pragmatic adaptations to support future evaluation and implementation of cognitive rehabilitation for ICU survivors.

trial registrationThe study was prospectively registered on the Open Science Framework (https://osf.io/b57fv/overview).

Indexed as

Cognitive DysfunctionCritical CareCritical IllnessAgedCognitive TrainingDenmarkFeasibility StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedResearch Designcognitive rehabilitationcritical illness survivorsfeasibility studyintensive care unitrandomised controlled design

Identifiers

PMID41975232
PMCPMC13076237

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.