Evidence map›Paper›PMID 41975125›Full record

ArticleArchives of toxicology2026

Distinct Ca

Andrea Guidarelli, Andrea Spina, Gloria Buffi, Mara Fiorani, Orazio Cantoni

Abstract read
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea GuidarelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. andrea.guidarelli@uniurb.it.ORCID 0000-0001-8621-3223
Andrea SpinaDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Gloria BuffiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Mara FioraniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Orazio CantoniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinically relevant concentrations of arsenic trioxide (ATO) induce apoptosis in NB4 cells through a complex, yet poorly defined interplay between endoplasmic reticulum-derived Ca

Indexed as

Arsenic TrioxideCalciumMitochondriaNADPH Oxidase 2Reactive Oxygen SpeciesApoptosisArsenicalsCalcium SignalingCell Line, TumorHumansInositol 1,4,5-Trisphosphate ReceptorsLeukemia, Promyelocytic, AcuteOxidative StressOxidesRyanodine Receptor Calcium Release ChannelSuperoxidesArsenicalsArsenic TrioxideCalciumInositol 1,4,5-Trisphosphate ReceptorsNADPH Oxidase 2OxidesReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelSuperoxidesAcute promyelocytic leukemiaApoptosisArsenic trioxideInositol 1,4,5-trisphosphate receptorMitochondrial permeability transitionMitochondrial superoxideNADPH oxidase 2Ryanodine receptor

Identifiers

PMID41975125
PMCPMC13309452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.