Evidence map›Paper›PMID 41975038›Full record

ArticleNatural products and bioprospecting2026

Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase.

Roland Hellinger, Paula Schwarz, Jonathan Dieringer, Carina Ebermann, Kirtikumar B Jadhav, Markus Muttenthaler, Christian W Gruber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roland HellingerCenter for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-8955-8793
Paula SchwarzCenter for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Jonathan DieringerCenter for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Carina EbermannCenter for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Kirtikumar B JadhavInstitute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090, Vienna, Austria.
Markus MuttenthalerInstitute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090, Vienna, Austria.
Christian W GruberCenter for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria. christian.w.gruber@meduniwien.ac.at.ORCID http://orcid.org/0000-0001-6060-7048

Funding

Austrian Science Fund 10.0.217.224/P366736
6 · The paper itself

Abstract

Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are a notable class, yet their distribution, diversity, and targets remain underexplored. Here, eleven tropical Psychotria species were screened for cyclic cysteine-rich peptides, with extracts showing concentration-dependent inhibition of human prolyl oligopeptidase (POP). Peptidomics combining mass spectrometry and transcriptome mining revealed multiple inhibitory peptides. From Psychotria solitudinum, which contained 37 peptides, a novel peptide (psysol 3) was purified and sequenced. Its synthetic analogue inhibited POP with an IC

Indexed as

CyclotideCystine-knot peptidePeptide-protease inhibitionPeptidomicsPlant peptide discoveryProlyl oligopeptidase

Identifiers

PMID41975038
PMCPMC13076805

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.