The Clinical Significance of KIFs in Cervical and Endometrial Cancer: from Mechanisms to Biomarker and Therapeutic Potential.

Cervical and endometrial malignancies are significant public health issues, with significant female health implications due to high prevalence and mortality. The cancers need to be addressed by improved understanding of their molecular mechanisms and identification of novel treatment approaches. Among the pivotal molecular mediators, kinesin family proteins (KIFs)- a group of intracellular transport motor proteins and regulators of cellular activity- have emerged as potential targets since they play a pivotal role in cancer biology. This review underscores the relevance of KIFs in cervical and endometrial cancers due to their role in oncogenic signaling pathways and clinical significance as well as in therapeutic potential. It is established that certain KIFs are overexpressed in both types of cancers and are responsible for tumorigenesis and increased cell growth, migration, and invasive capacity. The proteins play significant roles in regulatory pathways including PI3K/Akt and Wnt/β-catenin, which are critical for tumor growth and survival. Clinically, their elevated levels correlate with aggressive disease and unfavorable prognosis, implying their potential as prognostic or diagnostic biomarkers. Targeting KIFs presents a promising therapeutic approach as blockade of their activity can inhibit tumor growth and cooperate with conventional chemotherapy. Conclusion, KIFs are involved in the pathogenesis of cervical and endometrial cancers. More research into their molecular interactions and biological activities may unveil new therapeutic avenues and, in the end, improve clinical management and outcomes for patients with these prevalent gynecologic malignancies.