ArticleCellular & molecular immunology2026
MAIT cell plasticity generates CD4
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Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Commentary: Yin and Yang of MAITs in HCC: balancing type 1 vs. type 17 signaling.Cellular & molecular immunology · 2026Article
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Authors and funding
21 authors.
Sicheng FuDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. fsc@ustc.edu.cn.
Maoyu TangDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Changfeng ZhaoDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Sanwei ChenDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Miya SuDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Jun PanDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Yuwei ZhangDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xiaohu WangDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wenhao JiaDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xinmin ChuDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Shi ChenDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Yusheng ChenInsitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Lijian ChenDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Tengchuan JinDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID 0000-0002-1395-188X
Zhigang TianDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Yubei SunDepartment of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Yeben QianDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China. yebenqian126@126.com.
Lianxin LiuDepartment of Hepatobiliary Surgery, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. liulx@ustc.edu.cn.ORCID 0000-0002-3535-6467
Hua WangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. wanghua@ahmu.edu.cn.ORCID 0000-0002-2605-5697
Huimin ZhangDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. hmzhang@mail.ustc.edu.cn.
Li BaiDepartment of Health Management Center of the First Affiliated Hospital, State Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. baili@ustc.edu.cn.ORCID 0000-0002-9028-1920
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucosal-associated invariant T cells (MAITs) are enriched in the liver and closely related to human hepatocellular carcinoma (HCC), but their role is controversial. Whether and how the plasticity of MAITs modulates HCC progression remain to be explored. Here, we revealed that CD4
Indexed as
Carcinoma, HepatocellularCD4-Positive T-LymphocytesCell PlasticityLiver NeoplasmsMucosal-Associated Invariant T CellsAnimalsCell DifferentiationCell Line, TumorCell ProliferationDisease ProgressionGlycolysisHumansInterleukin-17KynurenineSignal TransductionTh17 CellsInterleukin-17KynurenineCD4+ MAITGlycolysisHCCMAIT cell plasticityMetabolic crosstalkTh17 polarization
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.