ArticleNature medicine2026
Plasma proteomic signature of the human menstrual cycle.
Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Clinical potential of fluid-based biomarkers for recurrent implantation failure: a systematic review.Frontiers in endocrinology · 2026Pooled it
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Authors and funding
10 authors.
Funding
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Abstract
The menstrual cycle is one of the most fundamental biological rhythms in human physiology, yet its systemic molecular changes remain poorly understood. Here we show that the menstrual cycle is accompanied by widespread changes in the circulating proteome. By profiling nearly 3,000 plasma proteins in 2,760 women from the UK Biobank, we identified 198 proteins that vary across the cycle, forming distinct temporal patterns aligned with menstrual phases. These proteins include reproductive hormones, cytokines and growth factors, many of which are enriched in endometrial tissue and expressed in epithelial and stromal cell types, highlighting their biological specificity. Several proteins were linked to common reproductive disorders, including endometriosis, leiomyoma and abnormal bleeding. Finally, we developed a proteomic score on the basis of 75 proteins that accurately predicts menstrual cycle phase. Together, these findings provide a systems-level atlas of menstrual cycle biology and inform biomarker discovery in women's health.
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