Evidence map›Paper›PMID 41974867›Full record

ArticleScientific reports2026

TLR7/8 signaling balances cytokine responses in neonatal monocytes.

S Dreschers, E Heiler, L Oppermann, C Gille, M Hornef, T W Orlikowsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S DreschersDepartment of Neonatology, University Children's Hospital Aachen, Aachen, Germany.
E HeilerDepartment of Neonatology, University Children's Hospital Aachen, Aachen, Germany.
L OppermannDepartment of Neonatology, University Children's Hospital Aachen, Aachen, Germany.
C GilleDepartment of Neonatology, University Children's Hospital Heidelberg, Heidelberg, Germany.
M HornefInstitute of Medical Microbiology, University Hospital Aachen, Aachen, Germany.
T W OrlikowskyDepartment of Neonatology, University Children's Hospital Aachen, Aachen, Germany. torlikowsky@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newborns are particularly vulnerable to nosocomial infection, but the underlying mechanisms are incompletely understood. Age-dependent differences in the expression of innate immune receptors and thus a reduced or delayed antimicrobial host response might contribute. Here we discovered that neonatal cord blood monocytes (CBMo) express lower levels of Toll-like receptor TLR8 but similar levels of TLR7 as compared to adult peripheral blood monocytes (PBMo). We investigated the TLR7/8 signal transduction by stimulating monocytes of adults (PBMo) and neonates (CBMo) with imiquimod (R

Indexed as

CytokinesMonocytesSignal TransductionToll-Like Receptor 7Toll-Like Receptor 8Fetal BloodHumansImidazolesImiquimodInfant, NewbornToll-Like Receptor AgonistsCytokinesImidazolesImiquimodresiquimodTLR7 protein, humanTLR8 protein, humanToll-Like Receptor 7Toll-Like Receptor 8Toll-Like Receptor AgonistsMonocytesNeonatal sepsisNeonatal TLR signalingNFκB signalingSustained inflammation

Identifiers

PMID41974867
PMCPMC13076771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.