Evidence map›Paper›PMID 41974798›Full record

ArticleScientific reports2026

Zinc- and fluoride-containing bioactive glass enhances angiogenesis-mediated bone regeneration via M2d macrophage activation.

Koki Otake, Takeru Kondo, Hiroaki Kakinuma, Yumi Sato, Sara Ambo, Amal Ashry, Kulapatch Engkatanachai, Jun Sato, Hiroshi Egusa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koki OtakeDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan.
Takeru KondoDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan. takeru.kondo.a7@tohoku.ac.jp.
Hiroaki KakinumaDepartment of Next-Generation Dental Material Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
Yumi SatoDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan.
Sara AmboDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan.
Amal AshryDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan.
Kulapatch EngkatanachaiDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan.
Jun SatoDepartment of Next-Generation Dental Material Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
Hiroshi EgusaDivision of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-Ku, Sendai-City, 980-8575, Japan. egu@tohoku.ac.jp.

Funding

Japan Society for the Promotion of Science 23K16081
6 · The paper itself

Abstract

Angiogenesis is crucial for bone regeneration because it supplies oxygen and nutrients to developing tissues. Immune cells, particularly macrophages, play an important role in regulating vascularization. The M2d macrophage subtype, which is phenotypically similar to tumor-associated macrophages, is characterized by high vascular endothelial growth factor (VEGF) expression; however, its role in regenerative angiogenesis and bone regeneration remains unclear. In this study, we developed a zinc- and fluoride-containing phosphate-based bioactive glass (ZFBG) by incorporating ZnO, CaF

Indexed as

AngiogenesisBone RegenerationCeramicsFluoridesGlassMacrophage ActivationMacrophagesNeovascularization, PhysiologicZincAnimalsCalcium CompoundsCell MovementHumansHuman Umbilical Vein Endothelial CellsMicePhosphorus Compoundsbioactive glass 45S5Calcium CompoundsFluoridesPhosphorus CompoundsSilicon DioxideSodium CompoundsVascular Endothelial Growth Factor AZincAngiogenesisBioactive glassBone regenerationFluorideM2d macrophagesZinc

Identifiers

PMID41974798
PMCPMC13077007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.