Synthesis of some novel coumarin-based heterocycles, elucidation of their antifungal behavior, molecular docking and computational studies.

Mahmoud F Ismail, Mounir A I Salem, Magda I Marzouk, Naglaa F H Mahmoud, Nashwa H Abdullah, Mustafa A S Gouda

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Mahmoud F IsmailDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia,Cairo, 11566, Egypt.

Mounir A I SalemDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia,Cairo, 11566, Egypt.

Magda I MarzoukDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia,Cairo, 11566, Egypt.

Naglaa F H MahmoudDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia,Cairo, 11566, Egypt.

Nashwa H AbdullahBotany and Microbiology Department, Faculty of Science, Capital University, Ain Helwan, Cairo, 11795, Egypt.

Mustafa A S GoudaDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia,Cairo, 11566, Egypt. mustafagouda@sci.asu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of coumarin-cyanoacetohydrazide hybrids was synthesized via efficient strategies that exploit the nucleophilic and electrophilic functionalities of the cyanoacetohydrazide scaffold. The designed framework incorporated a C-4 amino-substituted coumarin nucleus, enabling the construction of diverse fused and heteroannulated coumarin derivatives under mild conditions, affording moderate to excellent yields. The structures of all new compounds were confirmed by spectroscopic analyses (IR, MS,

Indexed as

Antifungal AgentsCoumarinsHeterocyclic CompoundsMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntifungal AgentscoumarinCoumarinsHeterocyclic CompoundsAntifungal activityComputational studyCoumarinCyanoacetohydrazideFused coumarin

Identifiers

PMID41974770

DOI10.1038/s41598-026-43854-5

PMCPMC13076868

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