Evidence map›Paper›PMID 41974720›Full record

ArticleNature communications2026

Engineering of genetically encoded programmable calcium channel inhibitory binders.

Xiaoxuan Liu, Sher Ali, Tien-Hung Lan, Decheng Wang, Brendan McKee, Tatsuki Nonomura, Siyao Liu, Feng Zhao, Michael X Zhu, Yun Huang and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoxuan Liu *Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Sher Ali *Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Tien-Hung Lan *Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Decheng WangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-1742-7460
Brendan McKeeCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.ORCID http://orcid.org/0009-0004-0302-0530
Tatsuki NonomuraCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Siyao LiuCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Feng ZhaoDepartment of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Michael X ZhuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5676-841X
Yun HuangDepartment of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0001-5950-9168
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA. qingdeng@purdue.edu.
Guolin MaCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA. gma@mdanderson.org.
Yubin ZhouCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA. yubinzhou@tamu.edu.ORCID http://orcid.org/0000-0001-7962-0517

Funding

Role of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9M
Epigenetic regulation in cardiac developmentR35HL166557 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Yun Huang · 2023 to 2026
$3.8M
Mutual reinforcement between somatic mutations and transcription factors in clonal hematopoiesisR01DK132286 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Xiaodong Cheng, Yun Huang · 2023 to 2026
$1.7M
Mutational cooperativity in TET2-associated hematological malignancies.R01CA240258 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HUANG, YUN · 2021 to 2025
$1.7M
Engineered Anisotropic and Vascularized Human Cardiac PatchR01HL146652 · NHLBI · TEXAS ENGINEERING EXPERIMENT STATION · PI ZHAO, FENG · 2020 to 2023
$1.4M
Engineering Smart Antibody-like Protein Scaffolds with precision switchesR01GM144986 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ZHOU, YUBIN · 2022 to 2025
$1.3M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP250468NCI NIH HHS R01 CA240258NHLBI NIH HHS R01 HL146652NHLBI NIH HHS R35 HL166557NIDDK NIH HHS R01 DK132286NIGMS NIH HHS R01 GM144986NIGMS NIH HHS R35 GM119787NIH Intramural Research ProgramU.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM144986
6 · The paper itself

Abstract

Store-operated Ca

Indexed as

Calcium Channel BlockersCalcium ChannelsCalcium Release Activated Calcium ChannelsORAI1 ProteinProtein EngineeringAnimalsAutistic DisorderCalciumCalcium SignalingChemogeneticsHEK293 CellsHumansLong QT SyndromeNFATC Transcription FactorsOptogeneticsStromal Interaction Molecule 1CalciumCalcium Channel BlockersCalcium ChannelsCalcium Release Activated Calcium ChannelsNFATC Transcription FactorsORAI1 ProteinStromal Interaction Molecule 1

Identifiers

PMID41974720
PMCPMC13077005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.