Observational studyThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2026
Acute lung allograft dysfunction predicts lung allograft failure: Construct validity of the 2026 International Society for Heart and Lung Transplantation spirometric definition.
Observational study in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Implementation of Spirometry Telemonitoring Programme in Lung Transplant Recipients: A Retrospective, Controlled Analysis of Clinical Outcomes.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionAcute lung allograft dysfunction (ALAD) has been proposed as a screening criterion to identify lung transplant recipients at increased risk for graft loss. ALAD was defined formally in a 2026 International Society for Heart and Lung Transplantation (ISHLT) Delphi consensus statement but has not been empirically evaluated. We sought to test the construct validity of the ISHLT ALAD definition by testing the hypothesis that ALAD is associated with increased risk of graft failure.
methodsWe included 86,885 spirometry measurements from 2,877 participants in the 8-center Lung Transplant Outcomes Group cohort. ALAD was defined as a ≥10% decline in FEV1 from the maximum value over the preceding 180 days and coded along with 90-day follow-up categories of resolved, persistent, progressive, and rapidly progressive. We assessed whether ALAD classifications diverged in predictions of time to death or re-transplantation in multivariable-adjusted time-dependent and landmark Cox proportional hazards models.
resultsALAD had a prevalence of 15%. While resolution was seen in 40%, ALAD conferred a 4.93-fold graft failure hazard (95% CI 4.47-5.45, 7.4 years median follow-up), independent of concurrent chronic or baseline lung allograft dysfunction (CLAD or BLAD) status. Resolved ALAD was not associated with increased graft failure risk, but persistent, progressive, rapidly progressive, and no follow-up FEV1 ALAD categories were associated with increasing hazards for graft failure. A 10-percent threshold for FEV1 decline and a 180-day window to set the FEV1 baseline demonstrated optimal discrimination.
conclusionThe 2026 ISHLT spirometric ALAD definitions identify graft failure risk, supporting their relevance in clinical interventions and further research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.