ArticleAnnals of medicine2026
The U-shaped correlation between the systemic immune-inflammation index and all-cause and cardiovascular mortality in hyperlipidemic patients: findings from NHANES 1999-2018.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship of systemic immune-inflammation index (SII) with mortality in hyperlipidemic patients remains unknown. In the present work, we evaluated SII for its ability to predict mortality incidence and examined its relationship with mortality of hyperlipidemic individuals.
methodsAltogether 27,903 hyperlipidemic cases were collected during 1999-2018 following the National Health and Nutrition Examination Survey (NHANES). SII was determined with complete blood count parameters. Our main results included all-cause and cardiovascular disease (CVD) mortality. We conducted Kaplan-Meier survival, restricted cubic spline (RCS), and Cox proportional hazards model analyses to assess the connection of SII to mortality among hyperlipidemic patients. To ensure that these results were reliable, we also conducted sensitivity and subgroup analyses.
resultsFor hyperlipidemic cases, their all-cause and CVD mortality rates were 12.651% and 3.916% separately. According to the Kaplan-Meier analysis, survival rates were low for individuals with high SII values. Multivariate Cox regression analysis indicated that for every one-unit elevation of lnSII, the all-cause mortality rate elevated by 19.7% (HR = 1.197, 95% CI: 1.117, 1.283), and the CVD mortality rate elevated by 30.1% (HR = 1.301, 95% CI: 1.131, 1.497). RCS suggested the U-shaped relationship of lnSII values with all-cause and CVD mortality (
conclusionsFor representative hyperlipidemic patients, SII shows the non-linear, U-shaped relationship with all-cause and CVD mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.