Evidence map›Paper›PMID 41974457›Full record

ArticleJournal for immunotherapy of cancer2026

Stem-like PD-1

Julia Busselaar, Douwe M T Bosma, Mo D Staal, Xin Lei, Yanling Xiao, Jannie Borst

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia Busselaar *Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-2402-4245
Douwe M T Bosma *Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Mo D StaalDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Xin LeiDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Yanling XiaoDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Jannie BorstDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands j.g.borst@lumc.nl.ORCID http://orcid.org/0000-0002-8043-5009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntigen-specific CD8

methodsWe use a mouse vaccination model to delineate by spectral flow cytometry and single-cell RNA sequencing the effects of CD4

resultsUpon vaccination in the absence of help signals, stem-like CD8

conclusionsOur data argue that stem-like CD8

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHepatocyte Nuclear Factor 1-alphaProgrammed Cell Death 1 ReceptorAnimalsCancer VaccinesCell DifferentiationFemaleHumansMiceMice, Inbred C57BLT-Cell ExhaustionCancer VaccinesHepatocyte Nuclear Factor 1-alphaPdcd1 protein, mouseProgrammed Cell Death 1 Receptorco-inhibitory moleculeImmunotherapyT cellTumor infiltrating lymphocyte - TILVaccine

Identifiers

PMID41974457
PMCPMC13084788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.