ArticleOrganic letters2026
Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triazolopyridines are an important class of heterocycles in the pharmaceutical industry and materials sciences. In particular, [1,2,3]triazolo[1,5a]pyridines have emerged as stable and versatile diazo compound precursors for performing carbene-mediated transformations. Despite their wide range of applications in chemical synthesis, their preparation is often reliant on oxidative cyclization methods using stoichiometric oxidants in an organic solvent, limiting their application in chemoenzymatic synthesis. We have recently discovered that vanadium-dependent haloperoxidase (VHPO) enzymes are effective catalysts for performing the oxidative cyclization of 2-pyridyl ketone hydrazones to give [1,2,3]triazolo[1,5a]pyridines through cryptic diazo formation. Herein, we have developed a chemoenzymatic protocol for conversion of 2-pyridyl ketones to [1,2,3]triazolo[1,5a]pyridines in a single vessel through the
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