Evidence map›Paper›PMID 41973927›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

mRNA m

Zhuoyue Shi, Kailong Wen, Wenqin Fu, Zhongyu Zou, Kathryn Guo, Nabilah H Sammudin, Meera J Patel, Xiangbin Ruan, Shivang Sullere, Shuai Wang and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. mNature reviews. Neuroscience · 2026
    Review
  2. mRNA mProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Recent advances in biomarkers for cardiac fibrosis.Frontiers in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Zhuoyue ShiDepartment of Neurobiology, The University of Chicago, Chicago, IL 60637.
Kailong WenCommittee on Neurobiology, Biological Sciences Division, The University of Chicago, Chicago, IL 60637.ORCID 0000-0002-7871-1086
Wenqin FuDepartment of Neurobiology, The University of Chicago, Chicago, IL 60637.ORCID 0000-0003-0630-0859
Zhongyu ZouDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.
Kathryn GuoDepartment of Neurobiology, The University of Chicago, Chicago, IL 60637.
Nabilah H SammudinCommittee on Neurobiology, Biological Sciences Division, The University of Chicago, Chicago, IL 60637.
Meera J PatelCommittee on Neurobiology, Biological Sciences Division, The University of Chicago, Chicago, IL 60637.
Xiangbin RuanDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.ORCID 0000-0002-6895-2070
Shivang SullereCommittee on Neurobiology, Biological Sciences Division, The University of Chicago, Chicago, IL 60637.
Shuai WangByrd Alzheimer's Center and Research Institute, The University of South Florida, Tampa, FL 33613.ORCID 0000-0002-9252-7496
Xiaochang ZhangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-5768-7470
Gopal ThinakaranByrd Alzheimer's Center and Research Institute, The University of South Florida, Tampa, FL 33613.ORCID 0000-0001-5523-6780
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.ORCID 0000-0003-4319-7424
Xiaoxi ZhuangDepartment of Neurobiology, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-6825-3221

Funding

RNA methylation in synaptic plasticity and drug-seekingR01DA043361 · NIDA · UNIVERSITY OF CHICAGO · PI ZHUANG, XIAOXI · 2017 to 2021
$2.8M
HHS | NIH | National Institute on Drug Abuse (NIDA) R01DA043361NIDA NIH HHS R01 DA043361
6 · The paper itself

Abstract

Animals learn and adapt to environmental changes. However, neural plasticity can also become maladaptive, leading to neurological and psychiatric disorders. How do we use known molecular mechanisms to harness the power of neural plasticity to prevent and treat diseases? Consolidating learning is known to require new protein synthesis. We found that mRNA m

Indexed as

AdenosineLearningNerve Tissue ProteinsProtein BiosynthesisRNA-Binding ProteinsRNA, MessengerAnimalsEpitranscriptomeMiceMice, KnockoutNeuronal PlasticityNeuronsRNA MethylationAdenosineNerve Tissue ProteinsRNA-Binding ProteinsRNA, MessengerYthdf1 protein, mouseneural plasticityRNA-binding proteinRNA methylationYTHDF1

Identifiers

PMID41973927
PMCPMC13099619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.