ArticlePloS one2026
A food-grade cell dissociation agent via regulatory pre-check framework.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Terminal sterilization of food-grade coatings for cellular agriculture: robustness against water quality and regulatory feasibility.Biotechnology reports (Amsterdam, Netherlands) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advancements in cell-based foods require materials that meet the highest food safety standards. Conventional cell dissociation agents, such as animal-derived trypsin, pose significant risks including viral contamination and allergenicity, which hinder their use in food production. To overcome this challenge, we propose a food regulatory pre-check framework, which prioritizes regulatory compliance before functional testing. Following this framework, we developed iDisper, a novel food-grade animal-free cell dissociation reagent composed of approved food additives (papain and trisodium citrate). Specifically, an optimized formulation containing 2 mg/mL papain demonstrated a dissociation efficacy and viability comparable to those of commercial agents in primary avian cells. Furthermore, iDisper demonstrated 8-month stability at -20 °C. This study validated the proposed framework as an effective strategy for developing safe and practical reagents for the cell-based food industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.