Evidence map›Paper›PMID 41973639›Full record

ReviewEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes2026

New Perfusion and Preservation Strategies for Donor Hearts.

Vincent Hendrik Hettlich, Hug Aubin, Maximilian Scherner, Bedri Ramadani, Artur Lichtenberg, Udo Boeken

Abstract readReview
In one paragraph

Review in European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vincent Hendrik HettlichDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Hug AubinDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Maximilian SchernerDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Bedri RamadaniDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Artur LichtenbergDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Udo BoekenDepartment of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, udo.boeken@med.uni-duesseldorf.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral systems for organ procurement and transportation are available in heart transplantation. Hypothermic storage of the cardioplegic heart has been the global standard since the 1980s and provides consistently reliable outcomes. However, ischemic time remains limited to approximately 4-5 h. SUMMARY: Recent preservation strategies aim to extend ischemic tolerance. This has been demonstrated for both modified hypothermic systems (e.g., SherpaPak, VitalPack) and machine perfusion devices (e.g., OCS, XVIVO). Beyond clinical performance, system selection is strongly influenced by economic factors. While conventional hypothermic storage is fully reimbursed, the substantially higher costs of advanced systems are typically covered only within the framework of clinical studies or must be financed by transplant centers. KEY MESSAGES: Hypothermic storage remains the standard method with proven long-term reliability, but is limited by restricted ischemic time. Novel preservation technologies extend ischemic tolerance and may improve transplantation logistics; however, their widespread implementation is currently limited by high costs and restricted reimbursement.

Indexed as

Heart TransplantationOrgan PreservationPerfusionHumansTissue DonorsHypothermiaIschemia timeOrgan preservationOrgan shortage

Identifiers

PMID41973639
PMCPMC13286470

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.