Evidence map›Paper›PMID 41973635›Full record

ArticleDiabetes care2026

Early Pregnancy Central Obesity and Risk of Prenatal and Postpartum Diabetes and Hypertensive Disorders.

Ana K Rosen Vollmar, Monique M Hedderson, Amanda L Ngo, Rana F Chehab, Alicia K Peterson, Mara B Greenberg, Lauren D Liao, Jennifer L Ames, Assiamira Ferrara, Yeyi Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana K Rosen VollmarDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Monique M HeddersonDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Amanda L NgoDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Rana F ChehabDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Alicia K PetersonDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Mara B GreenbergDepartment of Obstetrics and Gynecology, Kaiser Permanente Northern California, Oakland Medical Center, Oakland, CA.
Lauren D LiaoDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Jennifer L AmesDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.ORCID 0000-0002-7296-738X

Funding

Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum ComplicationsR01HL157666 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI ZHU, YEYI · 2021 to 2025
$3.7M
Prenatal Bisphenol A Exposure and Risk of Gestational DiabetesR01ES019196 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI FERRARA, ASSIAMIRA · 2013 to 2017
$3.0M
Kaiser Permanente Center for Upstream Prevention of Adiposity and Diabetes Mellitus (UPSTREAM)NHLBI NIH HHS R01 HL157666NHLBI NIH HHS R01HL157666NIEHS NIH HHS R01 ES019196NIEHS NIH HHS R01ES019196Translational Research Fellowship Program at Kaiser Permanente Northern California Division of Research
6 · The paper itself

Abstract

objectiveDespite limitations in using BMI to assess obesity, little is known about central obesity's role in pregnancy and postpartum cardiometabolic conditions. We investigated associations of central obesity with perinatal cardiometabolic conditions, independently and jointly with BMI. RESEARCH DESIGN AND

methodsWe examined associations of early pregnancy central obesity measures (waist circumference, waist-to-hip ratio, waist-to-height ratio, and body roundness index) with gestational diabetes mellitus, hypertensive disorders of pregnancy, postpartum prediabetes/diabetes, and postpartum chronic hypertension using modified Poisson (prenatal outcomes) and Cox (postpartum outcomes) regression.

resultsAmong the 3,055 individuals in the study, there was a dose-response relationship between increasing central obesity and all outcomes, even after adjusting for BMI. Among individuals with healthy prepregnancy BMI, central obesity was associated with a higher risk of gestational diabetes mellitus (relative risks 1.92-2.42), postpartum prediabetes/diabetes (hazard ratios [HRs] 1.50-2.16), and postpartum chronic hypertension (HRs 2.04-3.63).

conclusionsEarly pregnancy central obesity measures may enhance perinatal cardiometabolic risk assessment, helping identify at-risk individuals who could be missed using BMI alone.

Indexed as

Diabetes, GestationalHypertensionObesity, AbdominalAdultBody Mass IndexFemaleHumansPostpartum PeriodPrediabetic StatePregnancyRisk Factors

Identifiers

PMID41973635
PMCPMC13191382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.