Evidence map›Paper›PMID 41973602›Full record

ArticleMicrobial genomics2026

Harnessing gastrointestinal microbial co-association networks to predict feed efficiency and methane emissions across beef and dairy cattle.

Pamela A Alexandre, Yuliaxis Ramayo-Caldas, Milka Popova, Ioanna-Theoni Vourlaki, Gilles Renand, Aurélie Vinet, Diego P Morgavi, Antonio Reverter

Abstract read
In one paragraph

Article in Microbial genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pamela A AlexandreCSIRO Agriculture and Food, St. Lucia, Brisbane, Queensland 4067, Australia.
Yuliaxis Ramayo-CaldasAnimal Breeding and Genetics Program, IRTA, Torre Marimón, 08140 Caldes de Montbui, Barcelona, Spain.
Milka PopovaUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMR Herbivores, Saint-Genes-Champanelle, France.
Ioanna-Theoni VourlakiAnimal Breeding and Genetics Program, IRTA, Torre Marimón, 08140 Caldes de Montbui, Barcelona, Spain.
Gilles RenandUniversité Paris Saclay, INRAE, AgroParisTech, GABI, 78350 Jouy-en-Josas, France.
Aurélie VinetUniversité Paris Saclay, INRAE, AgroParisTech, GABI, 78350 Jouy-en-Josas, France.
Diego P MorgaviUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMR Herbivores, Saint-Genes-Champanelle, France.
Antonio ReverterCSIRO Agriculture and Food, St. Lucia, Brisbane, Queensland 4067, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteric methane emissions from cattle pose a significant environmental concern and represent a substantial energy loss for the animal, necessitating the development of effective mitigation strategies. The gastrointestinal microbiota plays a crucial role in determining both feed efficiency and methane production. Still, the specific microbial signatures that predict these traits across different production systems remain poorly understood. This study aimed to identify common predictive microbial biomarkers for feed efficiency and methane emissions using co-association network analysis across contrasting cattle production systems. Rumen liquid and faecal microbiota from 55 Charolais heifers (beef) and 56 Holstein cows (dairy) were analysed using 16S rRNA gene amplicon sequencing. Phenotypic data included feed efficiency, methane yield and acetate/propionate ratio. Co-association networks were constructed using Partial Correlation and Information Theory to identify amplicon sequence variants (ASVs) directly connected to phenotypes. Multiple regression analysis determined the minimal ASV sets required to achieve optimal predictive accuracy. Rumen microbiomes consistently showed superior predictive performance compared to faecal communities across all traits. Network-selected ASVs explained substantial phenotypic variance across traits and production systems (

Indexed as

BacteriaCattleMethaneMicrobiotaAnimal FeedAnimalsFecesFemaleMaleRNA, Ribosomal, 16SRumenMethaneRNA, Ribosomal, 16Samplicon sequencingCharolaisHolsteinrumen liquid and faecal microbiota

Identifiers

PMID41973602
PMCPMC13075996

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.