Evidence map›Paper›PMID 41973551›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026

The pyruvate kinase activator etavopivat (FT-4202) limits pulmonary and systemic sequelae of sepsis in a mouse LPS model.

Youwei Chen, Hongmei Zhu, Lisheng Zhang, Weijia Mai, Shein-Chung Chow, Desmond Wai Loon Chin, Sylvie Guichard, Marcus Carden, Apoorva Jagadish, Rodolfo A Estupinan and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Youwei ChenDurham VA Health Care System, Durham, North Carolina, United States.
Hongmei ZhuDurham VA Health Care System, Durham, North Carolina, United States.
Lisheng ZhangDuke University Health System, Durham, North Carolina, United States.ORCID 0000-0002-9276-6454
Weijia MaiDuke University Health System, Durham, North Carolina, United States.
Shein-Chung ChowDuke University Health System, Durham, North Carolina, United States.
Desmond Wai Loon ChinNovo Nordisk, Copenhagen, Denmark.
Sylvie GuichardNovo Nordisk, Copenhagen, Denmark.ORCID 0000-0003-1143-2805
Marcus CardenNovo Nordisk, Copenhagen, Denmark.
Apoorva JagadishDuke University Health System, Durham, North Carolina, United States.
Rodolfo A EstupinanDuke University Health System, Durham, North Carolina, United States.
Ian WelsbyDuke University Health System, Durham, North Carolina, United States.
Timothy J McMahonDurham VA Health Care System, Durham, North Carolina, United States.ORCID 0000-0002-3404-3223

Funding

TRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6M
Red blood cell ATP export and transfusion in sepsisR01HL161071 · NHLBI · DUKE UNIVERSITY · PI Allan Doctor, TIMOTHY J MCMAHON · 2023 to 2026
$2.7M
BLRD VA I01 BX003478Forma LLC (Novo Nordisk) No grant number.HHS | National Institutes of Health (NIH) HL-161071NHLBI NIH HHS R01 HL161071NHLBI NIH HHS T32 HL007057U.S. Department of Veterans Affairs (VA) BX-003478
6 · The paper itself

Abstract

Sepsis is frequently characterized by abnormal O

Indexed as

Acute Lung InjuryLungPyruvate KinaseSepsis2,3-DiphosphoglycerateAdenosine TriphosphateAnimalsCytokinesDisease Models, AnimalLipocalin-2LipopolysaccharidesMaleMiceMice, Inbred C57BL2,3-DiphosphoglycerateAdenosine TriphosphateCytokinesLipocalin-2LipopolysaccharidesPyruvate Kinaseacute lung injuryATPerythrocytehypoxianeutrophil

Identifiers

PMID41973551
PMCPMC13142219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.