Evidence map›Paper›PMID 41973499›Full record

ArticleACS nano2026

Nicotinamide-Loaded Peptoid Nanotubes for Energy Regeneration in Acute Brain Injury.

Hui Du, Thi Kim Hoang Trinh, Olivia C Brandon, Renyu Zheng, Haoyu Wang, Kylie Corry, Thomas R Wood, Chun-Long Chen, Elizabeth Nance

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui DuDepartment of Chemical Engineering, University of Washington, Seattle Washington 98195, United States.ORCID 0000-0002-0618-4950
Thi Kim Hoang TrinhPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.ORCID 0000-0002-9906-5896
Olivia C BrandonDivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States.
Renyu ZhengDepartment of Chemical Engineering, University of Washington, Seattle Washington 98195, United States.
Haoyu WangDepartment of Chemical Engineering, University of Washington, Seattle Washington 98195, United States.
Kylie CorryDivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States.
Thomas R WoodDivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States.
Chun-Long ChenDepartment of Chemical Engineering, University of Washington, Seattle Washington 98195, United States.ORCID 0000-0002-5584-824X
Elizabeth NanceDepartment of Chemical Engineering, University of Washington, Seattle Washington 98195, United States.ORCID 0000-0001-7167-7068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute brain injuries such as perinatal asphyxia, stroke, and traumatic brain injury result in ischemia, oxidative stress, excitotoxicity, and inflammation, leading to a depletion of ATP. Nicotinamide adenine dinucleotide (NAD+) is crucial for ATP regeneration and DNA repair during postinjury recovery. However, the therapeutic benefits of NAD+ and its precursors, such as nicotinamide (NAM), are limited by challenges in achieving effective cell-specific intracellular delivery. In this study, we use a nanopeptoid delivery strategy to replenish the cellular redox state and increase energy production in the acutely injured brain. By self-assembling peptoids into tubular structures, we created biocompatible NAM-conjugated peptoid nanotubes (NAM-PNTs) that vary in tubular length. NAM-PNTs demonstrated significant therapeutic benefits by enhancing cell viability and replenishing intracellular ATP levels within 24 h of treatment in oxygen-glucose-deprived (OGD) BV-2 cells. In organotypic brain slices, NAM-PNT treatment promoted glial proliferation, reduced proinflammatory cytokines, and increased anti-inflammatory cytokines after OGD, an

Indexed as

Brain InjuriesNanotubesNiacinamidePeptoidsAdenosine TriphosphateAnimalsCell SurvivalEnergy MetabolismMiceMicrogliaRatsRegenerationAdenosine TriphosphateNiacinamidePeptoidsATPcell metabolismdrug deliverymicroglianeonatalpoly-N-substituted glycines

Identifiers

PMID41973499
PMCPMC13131050

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.