ArticleActa crystallographica. Section D, Structural biology2026
Radiation-induced peroxide rupture and its temperature-dependent repair probed by homogeneous X-ray irradiation.
Article in Acta crystallographica. Section D, Structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Dose-dependent structural and electron-density features in the lytic polysaccharide monooxygenase NcAA9D.Acta crystallographica. Section D, Structural biology · 2026Article
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5 authors.
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Abstract
Specific radiation damage frequently compromises structural analysis in macromolecular crystallography. However, it can also offer key mechanistic information. Here, we investigate the X-ray-induced radiolysis of the catalytic C5-peroxide adduct in crystals of the cofactor-independent enzyme urate oxidase. Using a top-hat X-ray beam to ensure homogeneous dose distribution, we monitored the occupancy of the peroxide species across extensive dose series at 100 K and room temperature (RT). We observe a fundamental kinetic phase transition between these thermal regimes. At RT, the peroxide decays rapidly following zero-order kinetics, consistent with a flux-limited regime where the radiolytically cleaved O
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