Evidence map›Paper›PMID 41973388›Full record

ArticleClinical journal of gastroenterology2026

Urinary bladder invasion secondary to dissemination of gallbladder cancer: an unusual presentation.

Ryotaro Watanabe, Tatsuya Koshitani, Shinsuke Hashidume, Keiu Kasho, Akitaka Yokomura, Hiroshi Takihara, Takahiro Takemoto, Masaaki Itoh, Naoki Nakajima

Abstract readCase Reports
In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryotaro WatanabeDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Tatsuya KoshitaniDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan. tkoshitani@aol.com.
Shinsuke HashidumeDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Keiu KashoDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Akitaka YokomuraDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Hiroshi TakiharaDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Takahiro TakemotoDepartment of Gastroenterology, Uji Tokushukai Medical Center, 145 Ishibashi Makishima-Cho Uji City, Kyoto, 6110041, Japan.
Masaaki ItohDepartment of Urology, Uji Tokushukai Medical Center, Kyoto, Japan.
Naoki NakajimaDepartment of Pathology, Uji Tokushukai Medical Center, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallbladder cancer is an aggressive malignancy that is often diagnosed at an advanced stage, with frequent metastatic spread. Urinary bladder invasion caused by disseminated gallbladder cancer is extremely rare. A 56-year-old man presented with gross hematuria. Imaging revealed tumors in the gallbladder and urinary bladder with peritoneal dissemination. Transurethral resection of the urinary bladder tumor showed adenocarcinoma. Immunohistochemical analysis demonstrated positivity for CK7 and CDX2 and negativity for CK20, findings inconsistent with urachal carcinoma. Biopsy specimens from the gallbladder tumor and bile duct stricture revealed poorly differentiated adenocarcinoma with an identical immunohistochemical profile, leading to a diagnosis of urinary bladder involvement from gallbladder cancer. Despite systemic chemotherapy, the patient died 10 months after treatment initiation. Pathological autopsy confirmed urinary bladder invasion caused by peritoneal dissemination. This case illustrates a rare presentation of gallbladder cancer with urinary bladder invasion causing hematuria and highlights the importance of considering disseminated disease when evaluating urinary bladder tumors in patients with gallbladder cancer.

Indexed as

AdenocarcinomaGallbladder NeoplasmsPeritoneal NeoplasmsUrinary Bladder NeoplasmsFatal OutcomeHematuriaHumansMaleMiddle AgedNeoplasm InvasivenessGallbladder cancerPeritoneal disseminationUrachal carcinomaUrinary bladder invasion

Identifiers

PMID41973388
PMCPMC13219099

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.