SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Red cell distribution width as a prognostic predictor for colorectal cancer: a meta-analysis.
Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeRed cell distribution width (RDW) is a simple, low-cost hematological indicator that reflects systemic inflammation and nutritional status. Nevertheless, its prognostic value in colorectal cancer (CRC) remains uncertain. The current meta-analysis aimed to determine the predictive value of preoperative RDW levels for postoperative survival outcomes in individuals with CRC.
methodsAdhering to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, the Cochrane Library, Embase, PubMed, and Web of Science were searched for studies investigating the correlation of RDW with survival outcomes in CRC. Meta-analysis was executed using Stata 15. Subgroup analyses investigated sources of heterogeneity.
resultsThe analysis incorporated 16 studies, involving 20,500 individuals with CRC. Pooled results indicated that an elevated preoperative RDW-coefficient of variation (CV) was related to poorer overall survival (OS) (multivariable-adjusted pooled hazard ratio [HR] = 1.27, 95% confidence interval [CI] 1.00-1.60, I
conclusionAn increased preoperative RDW was independently linked to adverse postoperative survival outcomes in individuals with CRC. RDW-SD may offer superior predictive capability. As an accessible and inexpensive biomarker, RDW holds potential clinical utility for postoperative risk stratification. Nonetheless, existing research is predominantly retrospective. Standardized thresholds and measurement timing for RDW are lacking. Thus, future prospective multicenter studies are required for standardized validation.
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