ArticleEuropean journal of pediatrics2026
Amikacin pharmacokinetics, target attainment, and predictors in critically ill children: a retrospective cohort.
Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We aimed to quantify amikacin pharmacokinetics (PK) and early target attainment using routine third-dose therapeutic drug monitoring (TDM) in pediatric intensive care unit (PICU) patients and to identify clinical covariates associated with volume of distribution (Vd) and clearance (CL). We conducted a retrospective cohort study of PICU patients who received intravenous amikacin between January 2022 and December 2023. Individual PK parameters were estimated using third-dose peak and trough concentrations via the Sawchuk-Zaske method. Clinical and laboratory covariates were evaluated for associations with Vd and CL. Among 210 patients, mean Vd was 0.59 ± 0.30 L/kg and mean CL was 0.08 ± 0.03 L/kg/h. Early target under attainment was frequent, with 23.3% of
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