Evidence map›Paper›PMID 41972768›Full record

ArticlemBio2026

Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress.

Alexandre Le Scornet, Yongjun Tan, Dapeng Zhang, Jue D Wang, Mee-Ngan F Yap

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandre Le ScornetDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yongjun TanDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, Missouri, USA.
Dapeng ZhangDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, Missouri, USA.ORCID 0000-0001-8535-7620
Jue D WangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-1503-170X
Mee-Ngan F YapDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-4213-4050

Funding

The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteriaR35GM127088 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jue D. Wang · 2018 to 2026
$3.9M
Evolution and consequences of multidrug resistant ribosomeR01AI150986 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YAP, M.-N. FRANCES · 2020 to 2024
$2.3M
NIAID NIH HHS R01 AI150986NIGMS NIH HHS R35 GM127088U.S. Department of Defense W81XWH-18-1-0122
6 · The paper itself

Abstract

Macrolide, lincosamide, and streptogramin (MLS) antibiotics are structurally distinct molecules that inhibit protein synthesis by binding overlapping sites within the 23S rRNA of bacterial ribosomes. The clinical utility of MLS antibiotics has diminished due to the dissemination of

Indexed as

Anti-Bacterial AgentsBacterial ProteinsPurinesRepressor ProteinsRibosomesStaphylococcus aureusDrug Resistance, BacterialErythromycinGene Expression Regulation, BacterialMacrolidesMethyltransferasesRNA MethylationRNA, Ribosomal, 23SAnti-Bacterial AgentsBacterial ProteinsErythromycinMacrolidesMethyltransferasespurinePurinesRepressor ProteinsRNA, Ribosomal, 23Santibiotic resistanceerythromycinmacrolidenucleotide metabolismPurRribosomeRNA methylationStaphylococcus aureus

Identifiers

PMID41972768
PMCPMC13170274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.