Evidence map›Paper›PMID 41972728›Full record

ReviewCells2026

Peroxiredoxins in Stroke: Friends and Foes.

Yingfeng Wan, Jingwei Zhang, Liheng Bian, Xiaoxiao Tan, Ting Chen, Guohua Xi, Ya Hua, Aditya S Pandey, Richard F Keep, Sravanthi Koduri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingfeng WanDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1176-2065
Jingwei ZhangDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7882-1832
Liheng BianDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Xiaoxiao TanDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Ting ChenDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0100-2289
Aditya S PandeyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6441-5334
Sravanthi KoduriDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3645-4584

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
NINDS NIH HHS NS-106746NINDS NIH HHS NS-116786NINDS NIH HHS R01 NS106746NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

Stroke, a leading cause of mortality and long-term disability, induces complex cascades of oxidative stress and neuroinflammation that exacerbate brain injury. The peroxiredoxin (Prx; Prdx) family, composed of six thiol-dependent antioxidant enzymes (Prx1-6), plays a pivotal role in regulating redox homeostasis and immune responses in the brain. This review synthesizes current knowledge on the isoform-specific roles of Prxs in both ischemic and hemorrhagic stroke, highlighting their dual and context-dependent functions. Intracellular Prxs generally protect neurons and maintain blood-brain barrier (BBB) integrity, while extracellular Prxs-particularly Prx1 and Prx2-act as damage-associated molecular patterns (DAMPs), activating toll-like receptor signaling and amplifying inflammation. Isoforms such as Prx3 and Prx4 exhibit mitochondrial and endothelial protective effects, respectively, whereas Prx6 demonstrates complex roles influenced by its acidic, Ca

Indexed as

PeroxiredoxinsStrokeAnimalsBlood-Brain BarrierHumansOxidative StressSignal TransductionPeroxiredoxinshemorrhagic strokeischemic strokeneuroinflammationoxidative stressperoxiredoxin

Identifiers

PMID41972728
PMCPMC13072289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.