Evidence map›Paper›PMID 41972707›Full record

ReviewCells2026

Bio-Nanovesicle-Based Approaches for Hair and Skin Regeneration: An Updated Concise Review.

Ramya Lakshmi Rajendran, Danyal Reyaz, Atharva Anand Mahajan, Chae Moon Hong, Kandasamy Nagarajan ArulJothi, Byeong-Cheol Ahn, Prakash Gangadaran

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ramya Lakshmi RajendranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0001-6987-0854
Danyal ReyazDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu 603203, Tamilnadu, India.
Atharva Anand MahajanAdvanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, Maharashtra, India.
Chae Moon HongDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0002-5519-6982
Kandasamy Nagarajan ArulJothiDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu 603203, Tamilnadu, India.ORCID 0000-0002-1514-9911
Byeong-Cheol AhnDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0001-7700-3929
Prakash GangadaranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0002-0658-4604

Funding

National Research Foundation of Korea NRF-2022R1I1A1A01068652
6 · The paper itself

Abstract

Skin and hair follicles regenerate through coordinated stem cell niches and cyclic signaling associated with transitions among anagen, catagen, and telogen phases. In alopecia and chronic skin diseases, follicular miniaturization, immune dysregulation, persistent inflammation, impaired vascularization, and a compromised stratum corneum barrier limit the effectiveness of conventional topical and systemic therapies. Bio-nanovesicles (BNVs), including natural extracellular vesicles such as exosomes and microvesicles, as well as engineered artificial or hybrid nanovesicles, offer a targeted, cell-free delivery platform for miRNAs, proteins, and growth factors. By modulating key pathways-Wnt/β-catenin, PI3K/AKT, MAPK/ERK, and TGF-β/BMP-BNVs have the potential to restore regenerative crosstalk, enhance angiogenesis, and help initiate hair and skin repair.

Indexed as

Extracellular VesiclesHairHair FollicleRegenerationSkinAnimalsHumansartificial nanovesiclesbio-nanovesiclesdermal papilla cellsexosomesextracellular vesicleshair regenerationskin regenerationWnt/β-catenin signaling

Identifiers

PMID41972707
PMCPMC13072364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.