ArticleCells2026
Cilia Dynamics in Primary Ciliary Dyskinesia: A Biophysical Characterization of the
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary ciliary dyskinesia (PCD) is a rare ciliopathy resulting in chronic oto-sino-pulmonary disease. PCD diagnosis can be achieved by a combination of different diagnostic and adjuvant tools, including high-speed video-microscopy analysis (HSVA). A founder variant has been described in Puerto Rico as the most common cause of PCD in the island. BACKGROUND/
objectivesIn HSVA, objective parameters such as ciliary beat frequency (CBF) and subjective parameters such as ciliary beat pattern (CBP) shed light on the biophysical properties of cilia. However, the subjective nature of CBP creates a gap in knowledge; characteristics such as the length, angle, and bending index of cilia are poorly described. Our goal is to quantify cilia dynamics of the
methodsWe analyzed images from HSVA of six patients with PCD homozygous for the founder variant and six healthy controls (HC) (
resultsWe found that ciliary length (PCD = 7.62 ± 0.95 μm, HC = 8.12 ± 1.36 μm,
conclusionsReduced angular excursion and amplitude in PCD demonstrate that the beating pattern of the
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