Evidence map›Paper›PMID 41972678›Full record

ArticleCells2026

Loss of the DCHS1 Intracellular Domain Expands Neurogenic Proliferation and Generates Van Maldergem-like Neurodevelopmental Defects.

Kathryn Byerly, Cayla Wolfe, Magdalena Brei, Hannah Parris, Savannah Fisher, Aimee Alston, Hanmei Dong, Peng Chen, Hai Yao, Fulei Tang and 8 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kathryn ByerlyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-9894-4496
Cayla WolfeDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Magdalena BreiDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0001-3045-4025
Hannah ParrisDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Savannah FisherDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Aimee AlstonDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Hanmei DongClemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, SC 29425, USA.ORCID 0000-0001-8374-8513
Peng ChenClemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, SC 29425, USA.ORCID 0000-0002-3883-4671
Hai YaoClemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, SC 29425, USA.ORCID 0000-0001-5130-5128
Fulei TangDepartment of Comparative Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0003-2102-1137
Jan GuzDepartment of Comparative Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.
Sarah DooleyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-7229-0148
Taylor NelsonDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0003-1524-5804
Brian LoizziDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0008-5912-0329
Ranan PhookanDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0005-0625-2449
Cortney GensemerDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0002-8492-3536
Sunil PatelDepartment of Neurosurgery, Medical University of South Carolina, Charleston, SC 29407, USA.
Russell A NorrisDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-8462-5726

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Jeryl Jones · 2018 to 2026
$24.7M
American Heart Association TPA34850095National Heart Lung and Blood Institute HL131546National Heart Lung and Blood Institute HL149696National Heart Lung and Blood Institute HL173930NIDCR NIH HHS DE021134NIGMS NIH HHS P20 GM121342NIGMS NIH HHS P20GM121342
6 · The paper itself

Abstract

Van Maldergem Syndrome (VMS) is a rare autosomal recessive disorder caused by pathogenic variants in the atypical cadherin genes

Indexed as

CadherinsCraniofacial AbnormalitiesIntellectual DisabilityNeurodevelopmental DisordersNeurogenesisAbnormalities, MultipleAnimalsBrainCell ProliferationFoot Deformities, CongenitalHand Deformities, CongenitalJoint InstabilityMiceNeurodevelopmentNeuronsProtein DomainsCadherinsDchs1 protein, mousecell polarityDachsousheterotopiaHippo signalingneurodevelopment

Identifiers

PMID41972678
PMCPMC13072099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.