ArticleCells2026
Mitochondria-Dependent Metabolic Reprogramming Enhances Myofibroblast Differentiation and Aggravates Bleomycin-Induced Pulmonary Fibrosis.
Kai Yazaki, Yosuke Matsuno, Yuki Yabuuchi, Sosuke Matsumura, Kenya Kuramoto, Kazufumi Yoshida, Masashi Matsuyama, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii and 3 more
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Kai YazakiDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0002-6566-6140 Yosuke MatsunoDepartment of Respiratory Medicine, Nikko Memorial Hospital, Hitachi 317-0055, Japan.
Yuki YabuuchiDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Sosuke MatsumuraDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Kenya KuramotoDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Kazufumi YoshidaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Masashi MatsuyamaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0002-8880-6951 Takumi KiwamotoDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0003-3918-9878 Yuko MorishimaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0002-7407-4243 Yukio IshiiDepartment of Respiratory Medicine, National Hospital Organization Ibarakihigashi National Hospital, Tokai 319-1113, Japan.
Kaori IshikawaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.
Kazuto NakadaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.
Nobuyuki HizawaDepartment of Respiratory Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0003-1822-2448 Funding
JSPS KAKENHI JP20K08560JSPS KAKENHI JP23K15182
6 · The paper itselfAbstract
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by irreversible fibrosis. Aberrant cell differentiation plays a crucial role in the development of IPF. Although recent studies have suggested that mitochondrial dysfunction may play a role in IPF, its direct impact on fibrosis remains unclear. This study aimed to clarify the role of mitochondria in lung cell differentiation and pulmonary fibrosis development by employing mito-mice ND6
Indexed as
BleomycinCell DifferentiationMitochondriaMyofibroblastsPulmonary FibrosisAnimalsFibroblastsIdiopathic Pulmonary FibrosisLungMacrophagesMaleMetabolic ReprogrammingMiceMice, Inbred C57BLTransforming Growth Factor beta1BleomycinTransforming Growth Factor beta1fibroblastmacrophagemitochondrial dysfunctionpulmonary fibrosis
Identifiers
PMID41972673
PMCPMC13072105
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