Evidence map›Paper›PMID 41972672›Full record

ArticleCells2026

Highlights of Tuft Cells in Mouse and Human Salivary Glands.

Michael E Rusiniak, Lara Shimagami, Victor Zanetti Drumond, Mariana Silveira Souza, Fernanda Luiza Araujo Lima de Castro, Chao Xue, Ming Zhang, Jun Qu, George Edward Chlipala, Mark Maienschein-Cline and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael E RusiniakDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY 14214, USA.
Lara ShimagamiDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY 14214, USA.
Victor Zanetti DrumondDepartment of Oral Surgery, Oral Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil.
Mariana Silveira SouzaDepartment of Oral Surgery, Oral Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil.ORCID 0009-0007-8194-1425
Fernanda Luiza Araujo Lima de CastroDepartment of Oral Surgery, Oral Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil.
Chao XueNew York State Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY 14203, USA.
Ming ZhangNew York State Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY 14203, USA.
Jun QuNew York State Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY 14203, USA.ORCID 0000-0002-1346-6809
George Edward ChlipalaResearch Informatics Core, Research Resources Center, University of Illinois Chicago, Chicago, IL 60607, USA.
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois Chicago, Chicago, IL 60607, USA.
Tarcilia Aparecida da SilvaDepartment of Oral Surgery, Oral Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil.ORCID 0000-0001-9623-7835
Silvia Ferreira de SousaDepartment of Oral Surgery, Oral Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270, Brazil.ORCID 0000-0001-7820-4749
Harim Tavares Dos SantosDepartment of Oral Biology, The State University of New York at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0002-6591-6808

Funding

UIC Center for Clinical And Translational Science: Advancing Health for AllUM1TR005438 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Niranjan Subhash Karnik, Robin J. Mermelstein · 2025 to 2026
$7.6M
The Role of Tufts Cells in Salivary Gland ImmunityR00DE032363 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Harim Tavares Dos Santos · 2025 to 2026
$494k
The Role of Tufts Cells in Salivary Gland ImmunityK99DE032363 · NIDCR · UNIVERSITY OF MISSOURI-COLUMBIA · PI TAVARES DOS SANTOS, HARIM · 2023 to 2024
$202k
NCATS NIH HHS UM1 TR005438NIDCR NIH HHS K99 DE032363NIDCR NIH HHS R00 DE032363NIDCR NIH HHS R00DE032363 (Project Number: 4R00DE032363-03; former award K99DE032363)Sjögren's Foundation High Impact GrantUniversity at Buffalo, State University of New York Start-Up
6 · The paper itself

Abstract

Tuft cells (TCs) are rare chemosensory epithelial cells that regulate mucosal homeostasis in multiple organs, but their role in salivary gland (SG) biology remains poorly defined. This study aimed to define TC structure in mice submandibular glands (SMGs), determine how TC loss affects gland organization and function, and evaluate whether TC abundance in human minor SGs is associated with Sjögren's disease (SjD) features. Specifically, TC ultrastructure and ductal localization were characterized in female and male C57BL/6J mouse SMGs by transmission electron microscopy and immunostaining. Wild-type and C57BL/6J-

Indexed as

Salivary GlandsTuft CellsAnimalsFemaleHumansMaleMiceMice, Inbred C57BLSalivaSjogren's SyndromeSubmandibular Glandsalivasalivary glandSjögren’stranscriptome and histologytuft cell

Identifiers

PMID41972672
PMCPMC13072126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.