Evidence map›Paper›PMID 41972668›Full record

ArticleCells2026

Modulation of miRNA Signature in Human Adipose Tissue After 3 Months of ω-3PUFA Supplementation.

James Hernandez, Matthew Lee, Mary Cochran, Ting Li, Panwen Wang, Dawn K Coletta, Cassandra Rau, Valentin Dinu, Eleanna De Filippis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James HernandezResearch Department, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.ORCID 0009-0009-8879-7360
Matthew LeeGenomic and Computational Biology, Center of Biomedical Research, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mary CochranBarrett, The Honors College, Arizona State University, Tempe, AZ 85281, USA.
Ting LiResearch Department, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
Panwen WangDepartment of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
Dawn K ColettaDepartment of Medicine, College of Medicine, University of Arizona, Tucson, AZ 85724-5017, USA.ORCID 0000-0001-5819-5152
Cassandra RauBarrett, The Honors College, Arizona State University, Tempe, AZ 85281, USA.
Valentin DinuCollege of Health Solutions, Arizona State University, Tempe, AZ P.O. Box 879020, USA.ORCID 0000-0001-6192-7836
Eleanna De FilippisEndocrinology Division, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.ORCID 0000-0002-5622-6709

Funding

arizona health department ADHS14-00003606Katryn H. and Roger Penske Career Development Award in Endocrinology in Honor of Dr. Ian Hay 00Mayo Clinic Foundation 00NIH HHS 1KL2TR002379-00
6 · The paper itself

Abstract

Obesity is a persistent public health issue, often resulting in metabolic complications such as insulin resistance (IR). The secretion of pro-inflammatory cytokines from adipose tissue (AT) is increased during obesity, contributing to the impairment of systemic insulin sensitivity. While interventions in animal models have shown that reducing inflammation restores insulin sensitivity, human studies reducing systemic inflammation have produced inconsistent results. We recently demonstrated that three months of high-dose (4 g/daily) ω-3PUFA (fish oil, FO) supplementation improved insulin sensitivity, and decreased systemic and AT inflammation in individuals with obesity (BMI  ≥  30 kg/m

Indexed as

Adipose TissueDietary SupplementsFatty Acids, Omega-3MicroRNAsAdultFemaleGene Expression ProfilingGene Expression RegulationHumansInflammationInsulin ResistanceMaleMiddle AgedObesityFatty Acids, Omega-3MicroRNAsadipose tissuehuman studiesinflammationinsulin resistancemiRNAobesityomega 3 PUFA

Identifiers

PMID41972668
PMCPMC13072192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.