Evidence map›Paper›PMID 41972613›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Detection of Synaptic Vesicle Glycoprotein 2A in Serum Using a Polypyrrole-Functionalized Graphene Oxide Electrochemical Immunosensor.

Yonghong Zhao, Le Li, Jiale Tao, Manying Yang, Chen Li, Xiaoqian Zhang, Yang Zhang, Shiguo Sun, Na Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yonghong ZhaoPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Le LiCollege of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China.
Jiale TaoPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Manying YangPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Chen LiPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Xiaoqian ZhangPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Yang ZhangPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.
Shiguo SunCollege of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China.
Na ZhaoPharmacy College of Shihezi University/Key Laborataty of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization of XPCC/Institute for Safflower Industry Research, Shihezi University, Shihezi 832002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early intervention is pivotal for mitigating the progression of Alzheimer's disease (AD). This study presents an electrochemical immunosensor targeting synaptic vesicle glycoprotein 2A (SV2A) to facilitate early AD diagnosis. A sensing interface was engineered using a nanocomposite of graphene oxide (GO) and 3-carboxyl polypyrrole (3-COOH-PPy). Leveraging the synergistic effects between the large specific surface area of GO and the superior conductivity of 3-COOH-PPy, the composite established an efficient electron transport network. This architecture provided abundant active sites for capture antibody immobilization while significantly enhancing interfacial electron transfer kinetics. Coupling this interface with an enzyme-mediated signal amplification strategy based on the horseradish peroxidase (HRP)-catalyzed TMB/H

Indexed as

Alzheimer’s diseaseconductive polymerimmunosensorsynaptic vesicle glycoprotein 2A

Identifiers

PMID41972613
PMCPMC13074477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.