Local Lung HIF-1α and VEGF Activation to Reverse Emphysema by a Sulfated Caffeic Acid Dehydropolymer.

Tien M Truong, Meghan L Thompson, Umesh R Desai, Masahiro Sakagami

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tien M TruongDepartment of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, USA.

Meghan L ThompsonDepartment of Medicinal Chemistry, School of Pharmacy, Center for Drug Discovery, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.ORCID 0000-0001-6731-1741

Umesh R DesaiDepartment of Medicinal Chemistry, School of Pharmacy, Center for Drug Discovery, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.ORCID 0000-0002-1976-6597

Masahiro SakagamiDepartment of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, USA.ORCID 0000-0002-1387-3009

Funding

National Institute of Health HL090586 and HL107152Virginia Commonwealth University Presidential Research Quest Fund

6 · The paper itself

Abstract

In emphysema, the alveolar septal structure is progressively destroyed, which is believed to be irreversible. However, as it has recently been linked to vascular endothelial growth factor (VEGF) deficiency, we hypothesized that VEGF stimulation can promote lung cell proliferation/migration to reverse emphysema. Our sulfated caffeic acid dehydropolymer, CDSO3, was thus examined in vitro and in vivo, given its VEGF-stimulating activity via ferrous ion (Fe

Indexed as

caffeic aciddehydropolymeremphysemahypoxia-inducible factor (HIF)reversalvascular endothelial growth factor (VEGF)

Identifiers

PMID41972567

DOI10.3390/biology15070564

PMCPMC13071980

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.