Evidence map›Paper›PMID 41972540›Full record

ReviewBiology2026

Long Non-Coding RNA-Derived Peptides as a Novel Source of Tumor Neoantigens: Expanding the Immunopeptidome Beyond Canonical Coding Regions.

Ismael López-Calvo, Inés Bao-Camacho, Samuel Martín-Revuelta, Cora Rey-Souto, Anahir Franco-Gacio, José Manuel Pérez-Martínez, Iván Sandino-Somoza, Álvaro Mourenza, Esther Rodríguez-Belmonte, Mónica Lamas-Maceiras and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ismael López-CalvoCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0009-0004-7378-3306
Inés Bao-CamachoCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0009-0003-3720-7363
Samuel Martín-RevueltaCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.
Cora Rey-SoutoCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.
Anahir Franco-GacioCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0009-0007-8002-6559
José Manuel Pérez-MartínezCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0009-0000-0134-0603
Iván Sandino-SomozaCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0009-0007-0747-3168
Álvaro MourenzaCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0000-0003-4926-3891
Esther Rodríguez-BelmonteInstituto de Investigación Biomédica de A Coruña (INIBIC), As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0000-0001-8243-1303
Mónica Lamas-MaceirasCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0000-0001-8025-2838
M Esperanza CerdánCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0000-0001-8540-1417
Aida Barreiro-AlonsoCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0000-0002-3017-8550
Ángel Vizoso-VázquezCentro Interdisciplinar de Química e Bioloxía (CICA), Universidade da Coruña, Campus de Elviña, As Carballeiras, s/n, 15071 A Coruña, Spain.ORCID 0000-0001-7310-2102

Funding

Fondo Europeo de Desarrollo Regional-FEDERInstituto de Salud Carlos III FORT23/00010Ministerio de Ciencia, Innovación y Universidades PID2021-124564OB-I00Xunta de Galicia ED431C 2024-01
6 · The paper itself

Abstract

Cancer immunotherapy has transformed the clinical management of several malignancies; however, its efficacy remains limited in tumors with low mutational burden and restricted availability of classical mutation-derived neoantigens. In this context, increasing evidence indicates that the tumor immunopeptidome extends far beyond canonical protein-coding regions, incorporating peptides derived from non-coding transcripts through non-canonical translation mechanisms. Long non-coding RNAs (lncRNAs), traditionally regarded as transcriptional or post-transcriptional regulators, have recently emerged as an unexpected source of small open reading frame-encoded peptides (lncPEPs). A subset of these peptides is processed and presented by major histocompatibility complex class I molecules, generating tumor-specific neoantigens capable of eliciting CD8

Indexed as

dark proteomeimmunotherapylncPEPMHC-Iprecision oncologyproteogenomicssmORFs

Identifiers

PMID41972540
PMCPMC13072341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.