Evidence map›Paper›PMID 41972501›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution.

Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantin RaabeFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, Vienna, Austria.ORCID 0000-0002-2679-545X
Predrag KalabaFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, Vienna, Austria.
Xuan Ling Hilary YongFaculty of Health, Medicine and Behavioural Sciences, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Australia.
Greta CrudeliDepartment of Neuronal Cell Biology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Sarah MelzerDepartment of Neuronal Cell Biology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Erik KeimpemaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Victor AnggonoFaculty of Health, Medicine and Behavioural Sciences, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Australia.
Markus MuttenthalerFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, Vienna, Austria.ORCID 0000-0003-1996-4646

Funding

Australian Research Council DP230102707Australian Research Council FT210100266Australian Research Council LE240100134Australian Research Council Future Fellowship FT220100485Austrian Science Fund P 34121-BEuropean Research Council 101041941European Research Council 101212909Ian Lindenmayer PhD Top-up ScholarshipResearch Training Program Scholarship from the Australian Government and UQ
6 · The paper itself

Abstract

The oxytocin/vasopressin (OT/VP) neuropeptide signalling system is essential for regulating social behaviour, emotion, learning, and memory, and its dysregulation is associated with multiple neurological disorders. However, accurately studying OT/VP signalling in the brain remains difficult due to widespread receptor expression, long peptide half-lives, and extensive diffusion. To address these challenges, we investigated three classes of photolabile protecting groups-coumarin, nitrophenylpropyl, and borondipyrromethene-to enable precise, light-triggered OT/VP release. These photocages allow controlled activation with one-photon (365-527 nm) or two-photon (730-780 nm) irradiation and do not generate cytotoxic by-products. Using these cages, we synthesised OT/VP photoprobes and characterised their photopharmacological properties at their neuronal receptors (OTR, V

Indexed as

NeuropeptidesOxytocinVasopressinsAnimalsCoumarinsHumansMiceNeuronsRatsSignal TransductionCoumarinsNeuropeptidesOxytocinVasopressinsneuropeptidesoxytocinphotocagesphotopharmacologyvasopressin

Identifiers

PMID41972501
PMCPMC13206411

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.